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Yang, MD, a gastroenterologist at the University of Pennsylvania in Philadelphia, said that in the past, animal experiments have suggested that long-term use of PPI may be associated with colorectal cancer. They conducted a study to analyze the relationship between the two.
The study was based on the British Open Physiotherapeutic Research Database (1987-2002) and included 4432 patients with colorectal cancer and 44,292 matched controls. All participants were over 50 years old and had no cancer within the first 5 years of follow-up.
The results showed that in the total analysis, with PPI ≥ 5 years, the risk of colorectal cancer does not increase. However, in the PPI high-dose group, there was a tendency to increase the risk of colorectal cancer, but there was no statistical difference. Patients with pernicious anemia also have no increased risk of colorectal cancer.
Dr Yang stressed that clinicians should be clearly aware that long-term use of conventional doses of PPI is not associated with a significant increase in the risk of colorectal cancer; however, they can not completely exclude long-term high-dose PPI treatment for more than 10 years and risk of colorectal cancer Increased relevance. Therefore, physicians should always treat the patient with the least effective dose of PPI.
Name
Textile printer
Print head
DX5
Printer size
33*43cm(33*60cm)
Printing speed
A4 photo/111s
Printng resolution
5760*1440dpi
Nozzles
90*6=540
Interface
USB2.0
Net weight/Gross weight
55Kg/60Kg
Printer size
750*630*510mm
Height adjustment
Automatic
Working power
110V/220V 50/60Hz 30-75W
Operation system
Windows 7/XP/2000/Vista etc
Temperature
5-35o
Proton pump inhibitors are not associated with colorectal cancer
Studies by American scholars have shown that long-term use of proton pump inhibitors (PPIs) is associated with hypergastrinemia, which leads to metabolic disorders that may be associated with the development of colorectal cancer, but long-term use of PPI does not increase the risk of colorectal cancer . (Gastroenterology 2007, 133: 748)