Studies have found that NBR1 plays a key role in regulating obesity-induced inflammation, which can lead to metabolic diseases. A study at the Sanford-Burnham Medical Institute has identified obesity as a new signaling protein that causes islet problems. The protein causes inflammation of adipose tissue, which in turn leads to metabolic diseases. Blocking this signal protein can prevent metabolic diseases, such as type 2 diabetes, and problems associated with inflammation caused by obesity.
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By comparing various body mass index (BMI) levels in healthy and obese people, the researchers found that men with metabolic syndrome had higher levels of NBR1 protein. The team then fed mice with different foods, some of which were provided with a high-fat diet in which the NBR1 gene was inactivated. Compared to normal mice, mice without NBRl protein have less inflammation and better glucose tolerance. The researchers also demonstrated that NBR1 binds to the MEKK3 protein and causes the production of adipose tissue inflammation.
"MEKK3 protein is a very attractive protein tissue because it can be targeted for treatment and may produce type 2 diabetes solution," Diaz Meco said. "The next important step is to look for inhibitors and reversal agents of the MEKK3-NBR1 binding protein. This will treat type 2 diabetes caused by insulin resistance."